A new eNeuro study from Augusta University explores whether cannabidiol, better known as CBD, could help interrupt that process. Using male 5XFAD mice, a widely used model of Alzheimer’s, researchers gave the animals inhaled CBD daily for four weeks and then examined how the treatment affected brain inflammation, immune signaling, and behavior…
CBD appeared to quiet both pathways. In the brains of the Alzheimer’s mice, the researchers found lower expression of IDO and cGAS after treatment, including in microglia and astrocytes in the entorhinal cortex, a brain region that plays a key role in memory and is affected early in Alzheimer’s. The treatment was also linked to lower levels of proinflammatory cytokines, including TNF-α, IL-1β, and IFN-γ, along with higher levels of the anti-inflammatory cytokine IL-10. The mice also showed fewer infiltrating macrophages in the brain, another sign that inflammatory activity had eased…